TP-Link Archer C6TP-Link Archer C6U
WIFI 5 AC1200
5 GHz: 867 Mbps (802.11ac)
2.4 GHz: 300 Mbps (802.11n)
WIFI 5 AC1200
5 GHz: 867 Mbps (802.11ac)
2.4 GHz: 300 Mbps (802.11n)
Dual-Core CPUDual-Core CPU
1× Gigabit WAN Port
4× Gigabit LAN Ports
1× Gigabit WAN Port
4× Gigabit LAN Ports
NO USB PORT
or any of USB functions

U in end of C6U is
for USB functions only
1× USB 2.0 Port
Supported Partition Formats:
NTFS, exFAT, HFS+, FAT32
Supported Functions:
FTP Server
Media Server
Samba Server
Open wrt supportedOpen wrt not supported as of now

Basically the U in Archer C6U stands for USB port and additional functions that are embedded due to USB compatibility. Open-wrt at time of writing this comparison is supported by Tp-link C6 only but hopefully would be added soon to Archer C6U too.

Both these routers are dual band routers based on Wifi 5 capability. We have wifi 6 routers too easily available in India now. For those who have multi floor house or big brick house a Mesh Wifi Router system is best suited for this job.